Melatonin prevented the elevation of leukocyte count and the decreased of hematocrit levels in burn-induced Wistar Rats

Background: Burns are commonly caused by thermal injuries that often encountered in everyday life. may cause tissue damage and infection. Melatonin, a hormone acts as an antioxidant anti-inflammatory, can be used supportive therapy patients with burns preventing excess damage, decreasing inflammatory response, extreme leukocyte increase. The study aims to investigate the effects of melatonin supplementation on count hematocrit levels male Wistar rats injury.Method: This was experimental animal randomized control group design. A total twelve healthy were divided into two groups. All induced 30% area. intraperitoneally administered at 0, 8, 16 hours after treatment, while placebo (aquadest) similar method. Leukocyte measured taking retroorbital venous blood 3, 24 treatment. Data analyzed Paired t-Test, Independent Mann-Whitney, or Wilcoxon test depend their normality.Results: There higher compared 3 treatment (T3) (p=0.050), but not 0 (T0) (T24) (p>0.05). increased both groups T3 comparison T0, however increment steeper group. no significant differences between T3, T24 than T24, although it statistically significant.Conclusion: Melatonin might have role rise injury. If confirmed further studies, potential for adjuvant management burns.